Allele Biotechnology Announces New advance in production of human stem cells

This week in the journal Scientific Reports (Nature Publishing Group) scientists from Allele Biotechnology describe an important advance in the generation of stem cells capable of producing all the different tissues of the human body. In an article entitled “Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA,” Allele’s scientists present the fastest and safest method yet for converting ordinary human skin cells into “induced pluripotent stem cells” (iPSCs).

The scientific efforts were led by Dr. Luigi Warren, whose pioneering work on “footprint-free” reprogramming using messenger RNA was the foundation for Allele’s breakthrough. Through the united efforts of Dr. Warren and the scientists at Allele Biotechnology, his technique was re-engineered to increase cell conversion efficiency and eliminate any use of potentially unsafe reagents, while substantially reducing the time and effort needed to make stem cells. Dr. Warren believes that because of its advantages this technology “should become the method of choice for iPSC cell banking.”

According to Dr. Jiwu Wang, corresponding author on the paper and CEO of Allele Biotechnology, “This advance in stem cell derivation will enable both fundamental scientific research and clinical applications which has been the mission of Allele Biotechnology from its inception.”

Allele Biotechnology and Pharmaceuticals Inc. is a San Diego-based biotechnology company that was established in 1999 by Dr. Jiwu Wang and colleagues. A research based company specializing in the fields of RNAi, stem cells, viral expression, camelid antibodies and fluorescent proteins; Allele Biotechnology has always striven to offer products and services at the cutting edge of research.

Allele Biotechnology and Pharmaceuticals Inc.
Jiwu Wang, Ph.D., 858-587-6645 Ext 3
President and CEO
fax: 858-587-6692
Press release by BusinessWire. Also see Yahoo!News, Reuters, The Herald, etc.

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Friday, September 14th, 2012 Allele Mail Bag, iPSCs and other stem cells, Open Forum

5 Comments to Allele Biotechnology Announces New advance in production of human stem cells

September 15, 2012

Teratoma data was not included in the paper but is available upon request.

September 16, 2012

Using the same technologies we reprogrammed patient-specific fibroblasts last month for a Scripps lab and achieved the same efficiency as reported in the paper.

September 18, 2012

Given the time and cost saved using the new mRNA method, and the quality of the cells being completely safe from any virus or integrated DNA, any ongoing project that still depends on episomal DNA or Sandai virus is going to be outdated in terms of technologies.

September 25, 2012

This paper had 1430 downloads in the first 7 days, compared to the journal’s average of 800 in the first 28 days, according to Nature Publishing’s own online tracking system.

[…] week, at “bulk conversion”, and with cells seeded at a much wider density range compared to our previous publications. These significant improvements will further facilitate high throughput, large scale iPSC […]

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