More Open through Blog and Social Networking

People at Allele have realized the importance of staying open when it comes to interacting with our customers, colleagues, contributors, and friends. Therefore, we will continue to open up more channels through network places such as FaceBook, Twitter, professional social networks, Wiki, blogs on google, yahoo. The purpose is for people who wants to know what’s going on at Allele will know, so that lab people can find new products in new fields, convenient equipment of much much lower costs; companies can find sub-licensing or outsourcing chances they would otherwise know exist; and any researchers and business people to exchange ideas with us in any way.

Of course, we welcome you whole-heartedly to post and discuss scientific ideas right here in our Blog/Forums. Feel free to ask questions about science behind our products, process of product development, test-run your idea, or simply throw stuff from your scientific mind to our wall and see what sticks. As a matter of fact, we worked on a number of products on suggestions by our customers and scientist friends through discussions over a drink or during intermission of a game.

Tags: Facebook, forum, networking, open discussion, social network, town hall meeting, twitter, wikipedia

Launch of Allele-iPS Product Line

Induced pluripotent stem cells, or iPS (or iPSC as some call it), are differentiated cells from adult that “regained” capabilities to differentiate into all 3 germ layer specific cell types. The iPS induction process currently involves using viral vectors to introduce 3 or 4 cDNAs, which seemed surprisingly simple considering how complex it is for stem cells to go through each differentiation pathway.

The potentials of using iPS as models for research, cell assay systems, drug screening, toxicological testing, etc., seem to be tremendous at this point. However, for therapeutic use, the biggest hurdle standing in the way is the tendency of these iPS cells to form tumors once transplanted. It could be due to the oncogenic nature of the stemness inducing cDNAs themselves, or the retrovirus or lentivirus used for bring the cDNAs into the cells. A number of labs like that of Sheng Ding at Scripps, San Diego (Li et al., 2009), and Doug Melton at Harvard (Huangfu et al., 2008a; Huangfu et al., 2008b), are screening chemicals that would replace the use of some or maybe eventually all of the cDNAs. Such advances may help mitigate the oncogenic effects possibly associated with the inducing genes. Using non-integrating vectors as carriers would be preferred method for gene transfer if the retroviral or lentiviral vectors are the cause of tumors from iPS.

Today is the day that Allele launches its iPS product line, officially in this exciting field as one of the very first companies that produce products to make iPS research easier for everybody. New products in the pipeline include those for iPS induction and detection, stem cell culturing, differentiation tracking, and safer, novel delivery methods. It is just the beginning!

Huangfu, D., Maehr, R., Guo, W., Eijkelenboom, A., Snitow, M., Chen, A.E., and Melton, D.A. (2008a). Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nature biotechnology 26, 795-797.
Huangfu, D., Osafune, K., Maehr, R., Guo, W., Eijkelenboom, A., Chen, S., Muhlestein, W., and Melton, D.A. (2008b). Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature biotechnology 26, 1269-1275.
Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., Hao, E., Hayek, A., Deng, H., and Ding, S. (2009). Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell stem cell 4, 16-19.

Tags: antibodies, cancer stem cells, CSCs, iPS, lentivirus, Nanog, Oct3, oncogenic, primer set, reprogramming, retrovirus, stem cells, tumor

Meeting with Congresswoman Susan Davis’ Staff on Small Business Grants

Allele Biotech’s CEO Jiwu Wang participated in a meeting between a local biotech business organization “SBIR San Diego” and a representative of local Congresswoman Susan Davis. We had the opportunity to explain our positions on government funding for small business, particularly in the biotech area. We want to see that the SBIR law be extended in its form that is most aligned with its original intention of helping small business innovative research that would not have been otherwise possible.

As one of the participating SBIR members who told each company’s own “story”, Dr. Wang described that Allele Biotech was founded by 5 SBIR grants in 99 when he was still a postdoc at UCSD. Dr. The grants helped the company make its first product and deal by securing patent positions in one of most important research fields in the last decade, RNAi, and out-licensing the rights to Promega. Allele Biotech has since developed its own marketing and sales force, reinvested in formulating viral based RNAi with state-of-the-art fluorescent markers. Allele is currently waiting to start a phase II SBIR project for the NCI on cancer diagnostics.

Coinciding with President Obama’s announcement of federal programs to help small business today, the meeting had an overtone reflecting the general mood about economy’s direction in the nation. Like many research-oriented biotech companies, Allele’s scientists plan to apply for the Stimulus funds through the NIH’s Challenge Grants, in the areas of induced stem cells (iPS) and cancer stem calls (CSCs), which are Allele’s next new product line focus.

Tags: biotech, Challenge Grants, innovative research, NIH grants, San Diego, sba, SBIR, small business, stimulus package, Susan Davis

NIH Challenge Grant, First Released Program Based on the Stimulus Fund

At least 200 million dollars will be channeled through a new, one off mechanism called the Challenge Grants that were designed as jumpstart funds for 2-year projects. The review process will be quicker than normal; the start date will be by the end of September 09. Among the topics are 15 areas designated as Specific Challenge Topics by the NIH, and high priority topics that individual institute such as the NCI added by their choices. For instance, the Clinical Proteomic Technologies for Cancer program, of which Allele is a participant through a cancer marker antibody development project, is running several proteomic related topics that the Challenge Grants will fund.

Many new areas such as iPS, cancer stem cells, and resource development for stem cells are among the selected topics. All domestic institutions, academic or for-profit, are encouraged to apply. This announcement came a couple of weeks after the passage of the stimulus bill, from the NIH that does not yet have a permanent director or a HHS boss, one has to commend it as efficient work with focus. We are expecting that more programs are to come every week here on out until it becomes clear how all ARRA (The American Recovery and Reinvestment Act of 2009 or the stimulus fund) will be spent in the biomedical research field.

Tags: 200 million, Allele, antibody selection, ARRA, Challenge Grants, iPS, NCI, NIH, stem cells, stimulus package

SBIR Program in Danger of Dissolution

By a process of stealth evasion of detection, a sentence was inserted by yet unknown congress persons, SBIR & STTR were expressly stricken from the NIH portion of the stimulus bill just signed into law by President Obama, effectively removing almost $250 million in SBIR/STTR award funding that is badly needed by hundreds or even thousands of companies.

There has been a sentiment among academic colleagues that removing the SBIR/STTR programs will give 2.5% more money to university labs. That is probably a shared view by most professors; exceptions may include those who also function as PIs on STTR projects (STTR was created to allow for such cases) or consultants on SBIR projects through companies they often co-founded. For graduate students and postdocs, who may agree with such view because they too want more grant money to the labs, it is also important to know that a majority of the students and postdocs will work for SBIR supported or eligible companies. Biotech industry has never been a labor-intensive industry and therefore, even more than the 80% of general US population who are employed by small businesses, workers in this industry are likely to have a small business as their job provider. And there is nothing wrong with that—small companies are still the engine for innovation and model for efficiency and flexibility.

On March 20, just a few weeks from now, the SBIR program may stop to exist if a law that created it is not renewed. There are strong head winds for its renewal from special interest groups that want the money to be spent on large companies or venture-backed companies, because they are in need of cash infusion these days. SBIR is at risk. Considering the thousands upon thousands of layoff by the big pharma players in just the last few weeks, it is not difficult to understand their difficulties. The question is how effective the money can be used to provide jobs and create new areas for development.

If you want to have your voice heard, you can look up your congress representative or senators to tell them what you think. If you are going to do it, do it now.

1. Call your Senators, both their local and DC offices.
http://www.senate.gov/general/contact_information/senators_cfm.cfm
2. Call your Representative, both their local and DC offices.
http://www.house.gov/house/MemberWWW.shtml
3. Go to their web sites and use the email or webmail links to send them your message.

Tags: biotech, economy engine, economy recovery, government contracts, government grants, grants, jobs, NIH, research funding, SBIR, SBIR at risk, small business, small business innovative research, stimulus, STTR